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When a terrorist infected with a deadly viral plague boards the Stockholm to Geneva express train, he exposes all aboard to infection. 1,000 passengers are automatically doomed to death when the man placed in charge of the operation - Colonel MacKenzie (Burt Lancaster) - takes the decision to divert the train and crash it into oblivion at the Cassandra Crossing. However, the plan is thrown into doubt when passengers begin to make mysterious recoveries...