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Tectona Grandis - a Useful Herb: Sagwan - a Medicinal Plant
S. R. Acharya
Tectona Grandis - a Useful Herb: Sagwan - a Medicinal Plant
S. R. Acharya
The aqueous extract of Tectona grandis bark (ATG) was investigated for anti-inflammatory and antinociceptive activity at the doses (p.o.) of 100, 200 and 400 mg/kg body weight. The acetic acid-induced writhing response, tail immersion test and hot plate test were used to assess antino-ciceptive activity. For evaluation of anti-inflammatory activity, carrageenan induced paw edema served as acute model. At a dose, ATG (100, 200 and 400 mg/kg, p.o.) significantly attenuated the writhing responses induced by an intraperitoneal injection of acetic acid and at ATG (200 and 400 mg/kg, p.o.) significantly increased pain latencies in tail immersion and hot plate test. In addition, the higher doses of ATG (200 and 400 mg/kg, p.o.) were inhibited carrageenan induced paw edema. From acute oral toxicity studies (OECD-423 guidelines), no mortality was observed even at highest dose of ATG (2000 mg/kg, p.o.).
Media | Books Paperback Book (Book with soft cover and glued back) |
Released | April 23, 2012 |
ISBN13 | 9783659000607 |
Publishers | LAP LAMBERT Academic Publishing |
Pages | 88 |
Dimensions | 150 × 5 × 226 mm · 140 g |
Language | English |
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